Trimethylsilyl phenylacetate
trimethylsilyl phenylacetate
CAS: 2078-18-4
Molecular Formula: C11H16O2Si
Trimethylsilyl phenylacetate - Names and Identifiers
| Name | trimethylsilyl phenylacetate |
| Synonyms | Phenylacetic acid, monoTMS Trimethylsilyl phenylacetate rimethylsilyl2-phenylacetate trimethylsilyl phenylacetate PHENYLACETOXYTRIMETHYLSILANE Benzeneacetic acid, trimethylsilyl ester Acetic acid, phenyl-, trimethylsilyl ester |
| CAS | 2078-18-4 |
| InChI | InChI=1/C11H16O2Si/c1-14(2,3)13-11(12)9-10-7-5-4-6-8-10/h4-8H,9H2,1-3H3 |
Trimethylsilyl phenylacetate - Physico-chemical Properties
| Molecular Formula | C11H16O2Si |
| Molar Mass | 208.33 |
| Density | 0.982g/mLat 25°C(lit.) |
| Boling Point | 96-97°C0.7mm Hg(lit.) |
| Flash Point | 171°F |
| Vapor Presure | 0.0459mmHg at 25°C |
| Specific Gravity | 0.982 |
| Sensitive | 7: reacts slowly with moisture/water |
| Refractive Index | n20/D 1.478(lit.) |
Trimethylsilyl phenylacetate - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| UN IDs | NA 1993 / PGIII |
| WGK Germany | 3 |
| TSCA | No |
Trimethylsilyl phenylacetate - Introduction
trimethylsilyl phenylacetate is an organosilicon compound with the chemical formula C11H16O2Si. The following is a description of its nature, use, formulation and safety information:
Nature:
1. Appearance: colorless or light yellow liquid.
2. Density: about 0.965 g/mL.
3. Boiling Point: about 250-251 ° C.
4. Refractive index: about 1.495.
Use:
1. As a reagent in organic synthesis, it is commonly used in the preparation of protecting groups or reaction intermediates in organic synthesis reactions.
2. In the field of optoelectronics can be used as a precursor of organic silicon materials.
3. In the field of medicine can be used for the preparation of pharmaceutical raw materials and pharmaceutical intermediates.
Method:
trimethylsilyl phenylacetate is usually prepared by the following method:
1. The reaction of trimethylchlorosilane and phenyl ethyl ketone under alkaline conditions to generate trimethylsilyl phenylacetate, and the final product is obtained by distillation and purification.
Safety Information:
1. trimethylsilyl phenylacetate should be operated in a well-ventilated place, avoiding inhalation of steam or contact with skin and eyes.
2. If contact occurs, immediately rinse the affected area with plenty of water and seek medical attention immediately.
3. Storage should be sealed, away from the fire and oxidant.
4. When handling, follow proper laboratory safety procedures and wear appropriate personal protective equipment, such as gloves and goggles.
Nature:
1. Appearance: colorless or light yellow liquid.
2. Density: about 0.965 g/mL.
3. Boiling Point: about 250-251 ° C.
4. Refractive index: about 1.495.
Use:
1. As a reagent in organic synthesis, it is commonly used in the preparation of protecting groups or reaction intermediates in organic synthesis reactions.
2. In the field of optoelectronics can be used as a precursor of organic silicon materials.
3. In the field of medicine can be used for the preparation of pharmaceutical raw materials and pharmaceutical intermediates.
Method:
trimethylsilyl phenylacetate is usually prepared by the following method:
1. The reaction of trimethylchlorosilane and phenyl ethyl ketone under alkaline conditions to generate trimethylsilyl phenylacetate, and the final product is obtained by distillation and purification.
Safety Information:
1. trimethylsilyl phenylacetate should be operated in a well-ventilated place, avoiding inhalation of steam or contact with skin and eyes.
2. If contact occurs, immediately rinse the affected area with plenty of water and seek medical attention immediately.
3. Storage should be sealed, away from the fire and oxidant.
4. When handling, follow proper laboratory safety procedures and wear appropriate personal protective equipment, such as gloves and goggles.
Last Update：2024-04-09 02:00:44
